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A colorimetric and fluorescent merocyanine-based probe for biological thiols
Shu-Ping Wang1, Wu-Jian Deng, Dan Sun
1Department of Chemistry and The Key Laboratory of Analytical Sciences of MOE, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China.
Organic & Biomolecular Chemistry
|September 19, 2009
Abstract:
A new "dual-mode" chromogenic and fluorescent turn-on probe (2) for the selective sensing of biological thiols is reported. In MeOH-H(2)O cosolvent at physiological pH 7.40 (MeOH-H(2)O = 3:7), biological thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the chromo- and fluorophore merocyanine (3).

