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Updated: Jun 20, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury in the elderly
Khaled Abdel-Kader1, Paul M Palevsky
1Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, A 919 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Aging kidneys are more susceptible to acute kidney injury (AKI). This review covers age-related kidney changes, common AKI diagnoses, and management strategies specifically for elderly patients.
Area of Science:
- Nephrology
- Geriatric Medicine
- Physiology
Background:
- The aging kidney exhibits significant anatomical and physiological alterations.
- These changes predispose older adults to a higher risk of acute kidney injury (AKI).
Purpose of the Study:
- To review age-related changes in the kidney.
- To discuss diagnoses common in elderly patients with AKI.
- To examine the incidence, staging, evaluation, management, and prognosis of AKI in older adults.
Main Methods:
- Literature review of age-related kidney changes.
- Analysis of common AKI diagnoses in the elderly.
- Examination of AKI epidemiology, assessment, treatment, and outcomes in geriatric populations.
Main Results:
- Specific anatomic and physiologic changes in aging kidneys increase AKI risk.
- Certain diagnoses are more prevalent in elderly AKI patients.
- AKI management and prognosis in the elderly require tailored approaches.
Conclusions:
- Understanding age-related kidney changes is crucial for managing AKI in older adults.
- Early diagnosis and appropriate management can improve AKI outcomes in the elderly.
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