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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Updated: Jun 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder.

Jonathan T Ting1, Guoping Feng

  • 1Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.

Current Chemical Genomics
|September 22, 2009
PubMed
Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) research is shifting from serotonin to glutamate. New findings highlight glutamatergic synaptic dysfunction in the cortico-striatal-thalamo-cortical circuit, offering hope for novel OCD treatments.

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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

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Last Updated: Jun 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Published on: January 9, 2015

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Obsessive-compulsive disorder (OCD) affects 1-3% of the global population, incurring billions in treatment costs.
  • Current treatments like selective serotonin reuptake inhibitors (SSRIs) are ineffective for a significant portion of OCD patients.
  • The exact causes of OCD remain poorly understood, with limited evidence beyond the serotonin system.

Purpose of the Study:

  • To review evidence implicating glutamatergic synaptic dysfunction in OCD etiology.
  • To explore the role of the cortico-striatal-thalamo-cortical (CSTC) circuit in OCD.
  • To discuss genetic findings, animal models, and emerging glutamatergic treatments for OCD.

Main Methods:

  • Review of existing scientific literature on OCD.
  • Analysis of genetic studies related to glutamatergic dysfunction.
  • Examination of data from genetic animal models of OCD.
  • Evaluation of preliminary findings on glutamatergic agents for OCD treatment.

Main Results:

  • Growing evidence supports the critical involvement of the CSTC circuit in OCD.
  • Genetic studies indicate a role for glutamatergic dysfunction in OCD.
  • Animal models provide insights into OCD pathophysiology.
  • Glutamatergic neurotransmission modulators show preliminary promise for OCD treatment.

Conclusions:

  • Glutamatergic synaptic dysfunction is increasingly implicated in the etiology of OCD.
  • Targeting the glutamatergic system offers a promising avenue for developing novel OCD therapeutics.
  • Understanding the synaptic basis of OCD may lead to better treatments for related disorders.