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12:03
Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
Published on: July 8, 2012
Hematopoietic stem and progenitor cells and the inflammatory response
Siddhartha Jaiswal1, Irving L Weissman
1Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Annals of the New York Academy of Sciences
|September 23, 2009
Summary
Hematopoietic stem and progenitor cells (HSPCs) can migrate outside bone marrow to aid immune responses. This study investigates how these crucial cells survive toxic inflammatory environments.
Area of Science:
- Immunology
- Hematopoiesis
- Stem Cell Biology
Background:
- Vertebrate immune cells regenerate from hematopoietic stem cells (HSCs).
- Traditionally, HSCs were confined to the bone marrow niche.
- Emerging evidence shows hematopoietic stem and progenitor cells (HSPCs) are mobile and involved in peripheral immune responses.
Purpose of the Study:
- To investigate the mechanisms by which HSPCs survive in toxic inflammatory environments.
- To understand the resilience of mobile HSPCs during inflammatory conditions.
Main Methods:
- The abstract does not specify the methods used.
Main Results:
- The abstract does not specify the results.
Conclusions:
- The survival mechanisms of HSPCs in inflammatory milieus remain an open question.
- Further research is needed to elucidate how these critical cells are protected during inflammation.
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