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Related Experiment Video

Updated: Jun 20, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils

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Published on: November 11, 2025

[Neutrophils without CD16b receptors].

Norma E Riera¹, Marisa Rosso Saltó, Katia Canalejo

¹Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires.

|September 23, 2009

Summary

Rare CD16b deficiency, a neutrophil condition, was identified in two female patients. This finding is crucial for preventing transfusion complications and neonatal immune neutropenia.

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Last Updated: Jun 20, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils

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Published on: November 11, 2025

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

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Published on: February 7, 2025

Area of Science:

Immunology
Hematology

Background:

CD16b is an Fc gamma receptor on neutrophils, crucial for immune responses.
Neutrophil alloantigens and glycosyl phosphatidylinositol (GPI) linkage are vital for neutrophil function.

Observation:

Two female patients, aged 41 and 15, presented with distinct hematological conditions.
Flow cytometry revealed absent CD16b expression (null phenotype) in both patients.
No deficiencies in other neutrophil alloantigens or GPI linkage defects were observed.

Findings:

The CD16b null phenotype was confirmed in both patients without associated GPI anchor defects.
Clinical symptoms were not solely attributable to CD16b absence, suggesting compensatory mechanisms by CD32 and CD64.

Implications:

CD16b deficiency, occurring in <1% of Caucasians, necessitates consideration in transfusion medicine to prevent alloimmunization.
Awareness of this rare phenotype is essential for managing potential transient neonatal immune neutropenia in offspring of affected mothers.