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Updated: Jun 20, 2026
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
[Tolerance and autoimmunity. Novel therapeutic approaches]
Esteban Ciliberti1, Leandro Carambia, Sebastian Cavallin
1Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires. estabanciliberti@gmail.com
Medicina
|September 23, 2009
Summary
The immune system protects against pathogens but can cause autoimmune disease when self-reactive cells are not silenced. New therapies offer hope for managing autoimmune conditions and tissue damage.
Area of Science:
- Immunology
- Pathology
- Pharmacology
Context:
- The immune system distinguishes self from non-self to prevent pathogen attack.
- Immunological tolerance is crucial for preventing autoimmunity by silencing self-reactive immune cells.
- Dysregulation of tolerance leads to autoimmune diseases.
Purpose:
- To review the mechanisms of immunological tolerance and its failure in autoimmune diseases.
- To explore recent advances in the pharmacology of the immune system for treating autoimmune conditions.
- To discuss the potential and limitations of new therapeutic agents for autoimmune diseases.
Summary:
- The immune system, composed of innate and adaptive components, normally protects against pathogens while maintaining tolerance to self.
- Failure in silencing self-reactive T and B cells results in autoimmune diseases.
- Recent pharmacological advances offer novel therapeutic strategies to control immune-mediated tissue damage, though further research is needed.
Impact:
- Advances in understanding immune system regulation and autoimmune disease pathogenesis.
- Development of new biologic agents for managing autoimmune conditions.
- Potential for improved patient outcomes and reduced pathological tissue damage in autoimmune diseases.
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