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Ischemic Stroke ll: Pathophysiology

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 20, 2026

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

Published on: January 4, 2013

CT perfusion in acute stroke.

Niranjan Khandelwal¹

¹Department of Radiodiagnosis and Imaging, PGIMER, Sector 12, Chandigarh, India.

The Indian Journal of Radiology & Imaging

|September 24, 2009

Summary

This summary is machine-generated.

Early stroke diagnosis is crucial for limiting brain damage. CT perfusion imaging aids in the rapid detection of cerebral ischemia, improving patient outcomes.

Keywords:

CT perfusion Stroke cerebral ischemia

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Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

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Last Updated: Jun 20, 2026

Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels

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Published on: January 4, 2013

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

Area of Science:

Neurology
Radiology
Medical Imaging

Background:

Stroke is a complex neurological condition resulting from disrupted cerebral blood flow.
Timely diagnosis of stroke is critical for effective treatment and minimizing neuronal loss.
Delayed intervention in stroke leads to increased patient morbidity.

Purpose of the Study:

To elucidate the pathophysiology of cerebral ischemia.
To highlight the utility of CT perfusion in the early diagnosis of stroke.

Main Methods:

Review of the pathophysiology of cerebral ischemia.
Explanation of CT perfusion imaging techniques and their application in stroke detection.

Main Results:

CT perfusion offers significant advantages for the early diagnosis of stroke.
Understanding ischemia pathophysiology is key to interpreting CT perfusion findings.

Conclusions:

CT perfusion is a valuable tool for the rapid and accurate diagnosis of stroke.
Early detection via CT perfusion facilitates timely treatment, reducing neurological deficits.