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Updated: Jun 20, 2026
04:48
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
Published on: May 4, 2020
Oxidative status in iron-deficiency anemia
Jong-Ha Yoo1, Ho-Young Maeng, Young-Kyu Sun
1Department of Laboratory Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Kyonggi-do, Korea.
Journal of Clinical Laboratory Analysis
|September 24, 2009
Summary
Patients with iron-deficiency anemia (IDA) exhibit higher oxidative stress. Iron treatment normalized oxidant and antioxidant levels, suggesting oxidative stress plays a role in IDA pathogenesis.
Area of Science:
- Biochemistry
- Hematology
- Clinical Medicine
Background:
- Oxidative stress, an imbalance between free radicals and antioxidants, is implicated in iron-deficiency anemia (IDA) pathogenesis.
- Understanding oxidative status in IDA is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the oxidative status in female patients diagnosed with IDA.
- To evaluate the alterations in oxidative status following iron supplementation therapy.
Main Methods:
- Assessed oxidant activity, total antioxidant capacity, and catalase activity in 33 female IDA patients and 25 healthy controls.
- Utilized the free oxygen radicals test, free oxygen radicals defense assay, and a commercial spectrophotometer kit for catalase activity measurement.
Main Results:
- IDA patients showed significantly higher oxidant activity and lower total antioxidant and catalase activity compared to controls (P<0.05).
- Post-iron treatment, oxidant, antioxidant, and catalase levels in IDA patients normalized to control group levels (P>0.05).
Conclusions:
- Iron deficiency anemia is associated with increased oxidative stress, characterized by elevated reactive oxygen species and reduced antioxidant defenses.
- Iron therapy effectively mitigates oxidative stress in IDA patients, supporting the hypothesis of oxidative stress involvement in the condition.
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