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Related Experiment Video

Updated: Jun 20, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cells for liver repopulation.

Alejandro Soto-Gutierrez¹, Nalu Navarro-Alvarez, Hiroshi Yagi

¹Center for Engineering in Medicine and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Current Opinion in Organ Transplantation

|September 26, 2009

Summary

This summary is machine-generated.

Liver regeneration is unique, but mechanisms remain unclear. Research focuses on stem/progenitor cells for liver disease therapy, aiming to improve cell sources and delivery for better patient outcomes.

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Last Updated: Jun 20, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

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Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Published on: May 10, 2020

Area of Science:

Hepatology and Regenerative Medicine
Stem Cell Biology
Organ Engineering

Background:

The liver's remarkable regenerative capacity is not fully understood.
Cell transplantation is a promising alternative treatment for liver diseases.
Generating functional hepatocytes from stem/progenitor cells is a key research area.

Purpose of the Study:

To review current evidence on hepatic cell sources for liver regeneration.
To discuss the clinical applications of stem/progenitor-derived hepatocytes.
To explore future perspectives and tools for translating laboratory findings into clinical success.

Main Methods:

Review of current scientific literature on hepatic cell sources and transplantation.
Analysis of stem/progenitor cell differentiation toward hepatic lineages.
Evaluation of innovations in hepatocyte delivery, survival, and engraftment.

Main Results:

Several potential stem/progenitor cell sources for generating hepatocyte-like cells have been identified.
Standardization of methods for evaluating these cells is crucial for therapeutic development.
Organ engineering advancements offer new possibilities for improving liver repopulation.

Conclusions:

Clinical application of hepatic cell sources requires further investigation and standardization.
Future research should focus on optimizing cell delivery and engraftment for effective liver regeneration.
Translating laboratory advancements into clinical success necessitates collaborative efforts and innovative tools.