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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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Updated: Jun 20, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Biodegradable polymeric nanoparticles based drug delivery systems.

Avnesh Kumari1, Sudesh Kumar Yadav, Subhash C Yadav

  • 1Biotechnology Division, Institute of Himalayan Bioresource Technology, CSIR, Palampur, HP 176061, India.

Colloids and Surfaces. B, Biointerfaces
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Biodegradable nanoparticles offer improved drug delivery with enhanced bioavailability and controlled release. This review covers their synthesis, encapsulation, and therapeutic benefits for various diseases.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Biodegradable nanoparticles are increasingly utilized as drug delivery systems.
  • They offer advantages such as enhanced bioavailability, controlled release, and reduced toxicity.

Purpose of the Study:

  • To review the synthesis and encapsulation processes of biodegradable nanoparticles for drug delivery.
  • To highlight the therapeutic improvements achieved by nanoencapsulating drugs using various biodegradable materials.

Main Methods:

  • Literature review of nanoparticulate systems and their applications in drug delivery.
  • Discussion of general synthesis and encapsulation techniques for biodegradable nanoparticles.
  • Analysis of controlled release mechanisms and therapeutic value enhancement.

Main Results:

  • Biodegradable nanoparticles demonstrate significant potential in improving drug delivery efficacy.
  • Various materials like PLGA, PLA, chitosan, gelatin, polycaprolactone, and poly-alkyl-cyanoacrylates are effective carriers.
  • Nanoencapsulation leads to better control over drug release and increased therapeutic outcomes.

Conclusions:

  • Biodegradable nanoparticles represent a promising platform for advanced drug delivery.
  • Their tunable properties allow for tailored drug release profiles and improved treatment efficacy.
  • Further research into these systems can unlock new therapeutic possibilities.