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Enamine catalysis with low catalyst loadings--high efficiency via kinetic studies

Markus Wiesner1, Grégory Upert, Gaetano Angelici

  • 1Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.

Journal of the American Chemical Society
|October 2, 2009
PubMed
Summary

Researchers identified key rate-limiting steps in peptide-catalyzed enamine reactions. This discovery enables significantly lower catalyst loading for conjugate addition reactions, achieving unprecedented efficiency with low molecular weight catalysts.

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