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Invasive non-typhoidal Salmonella in Mozambican children

Inácio Mandomando1, Eusébio Macete, Betuel Sigaúque

  • 1Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Moçambique. inacio.mandomando@manhica.net

Tropical Medicine & International Health : TM & IH
|October 2, 2009
PubMed
Abstract

Insights

Invasive non-typhoidal Salmonella (NTS) in Mozambican children often presents with non-specific symptoms like fever and cough. High antibiotic resistance to common treatments poses a significant challenge for sepsis management.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Invasive non-typhoidal Salmonella (NTS) infections are a significant cause of childhood morbidity and mortality in sub-Saharan Africa.
  • Understanding the epidemiology and clinical characteristics of NTS is crucial for effective disease control.

Purpose of the Study:

  • To describe the epidemiology and clinical presentation of invasive non-typhoidal Salmonella (NTS) in Mozambican children.
  • To identify risk factors for mortality and analyze serotype distribution and antibiotic resistance patterns.

Main Methods:

  • Analysis of 401 invasive NTS cases in children admitted to Manhiça District Hospital (May 2001-April 2006).
  • Epidemiological data, clinical presentations, serotypes, and antibiotic susceptibility were examined.
  • Univariate and multivariate analyses were performed to identify risk factors.

Main Results:

  • Fever, cough, and increased respiratory rate were common symptoms; diarrhea was less frequent (29%).
  • Salmonella typhimurium (66%) and Salmonella enteritidis (25%) were the predominant serotypes.
  • High resistance rates were observed for ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole.

Conclusions:

  • Invasive NTS presentation in children is often non-specific, mimicking other infections.
  • Young age, severe malnutrition, diarrhea, and pneumonia are independent risk factors for death.
  • Widespread antibiotic resistance necessitates careful consideration of treatment options for suspected NTS sepsis.

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