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Direct and indirect modulation of neuronal calcium currents by G-protein activation
A C Dolphin1, E Huston, R H Scott
1Department of Pharmacology, St George's Hospital Medical School, London, U.K.
Biochemical Society Symposium
|January 1, 1990
Abstract:
Evidence is presented for modulation of the various components of neuronal Ca2+ currents by G-proteins and by gamma-aminobutyric acid B (GABAB) receptor activation. The mechanism of these interactions and the possible involvement of second messengers is discussed. The role of inhibition of Ca2+ channels in presynaptic inhibition of neurotransmitter release is examined.