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Related Experiment Videos

Doxazosin in 'resistant' hypertension.

D Maclean1, D G McDevitt

  • 1University Department of Clinical Pharmacology, Ninewells Hospital, Dundee, UK.

Journal of Human Hypertension
|October 1, 1990
PubMed
Summary

Doxazosin effectively treated patients resistant to beta-blocker and diuretic therapy. This drug was well-tolerated, though the study had limitations in its design and comparisons.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Clinical Therapeutics

Background:

  • Resistant hypertension requires additional therapeutic agents.
  • Beta-adrenoceptor blockers and diuretics are common first-line treatments.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of doxazosin as a third-line treatment.
  • To assess doxazosin's utility in patients with therapy-resistant hypertension.

Main Methods:

  • An open-label study design was employed.
  • Doxazosin was added to existing beta-blocker and diuretic regimens.
  • Patient outcomes were monitored for effectiveness and adverse events.

Main Results:

  • Doxazosin demonstrated effectiveness in patients resistant to baseline therapy.
  • The drug was generally well-tolerated by the study participants.
  • No direct comparisons were made with alternative third-line agents.

Conclusions:

  • Doxazosin is a viable and safe option for managing resistant hypertension.
  • Further comparative studies are needed to position doxazosin against other third-line therapies.

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