[Study of the process of diffusion of gentin tablets through the artificial lipid barrier]

Currently during medical treatment of the patients suffering with gastrointestinal system diseases, particular attention is being devoted to the medical remedies of plant origin, which allow its protracted use during these diseases without expressed negative influence on important functions and structures of organism. Study of the dependence of the diffusion rate of active substances presented here as a multi-component plant origin dosage form, from the dissolution profile of solid dosage form in gastrointestinal tract, is an actual biopharmaceutical problem, which gives an information about the completeness of release of the active substances from the dosage form and its bioavailability. Gentin tablets developed at the department of pharmaceutical technology of Tbilisi State Medical University, presents the phytopreparation recommended for the prevention and treatment of the diseases of gastro-intestinal system. In-vitro study of the diffusion kinetics of active compounds from gentin tablets were performed using membrane model "SARTORIUS" Sm 16750 (FRG), which allows study of the diffusion rate of medical substances in the conditions closely imitating gastro-intestinal tract. Obtained experimental data showed that gamma-pyronic compounds are better absorbed in intestines than in stomach, as the value of diffusion rate constant k(d) in intestinal juice (pH=6,8) is 9, 17 x 10(-3) cm/min, while k(d) in gastric juice (pH=1,2) is 1, 63 x 10(-3) cm/min, thus the diffusion process is much more intensive in intestinal media with pH=6,8.