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Updated: Jun 19, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Steroidal glycosides from Furcraea foetida and their cytotoxic activity
Akihito Yokosuka1, Tomoe Sano, Ken Hashimoto
1Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Hachiouji, Tokyo 192-0392, Japan. yokosuka@toyaku.ac.jp
Abstract:
Two new spirostanol glycosides (1, 2) and a new furostanol glycoside (3), together with nine known steroidal glycosides (4-12) were isolated from the leaves of Furcraea foetida (Agavaceae). The structures of the new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, HSC-2 human oral squamous carcinoma cells, and HSC-4 human oral squamous carcinoma cells.
