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Related Concept Videos

Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Synthesis of Phosphatidylcholine in the ER Membrane01:27

Synthesis of Phosphatidylcholine in the ER Membrane

The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...

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Related Experiment Video

Updated: Jun 19, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
08:49

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

[Phosphatidylethanolamine-binding protein (PEBP) in basic and clinical study].

Fang-Fang Li1, Shi-Jun Song, Ruo-Nan Zhang

  • 1Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|October 7, 2009
PubMed
Summary
This summary is machine-generated.

Phosphatidylethanolamine-binding protein (PEBP) is a multifunctional protein regulating cell signaling and cancer progression. Loss of PEBP function is linked to tumor metastasis and chromosomal abnormalities, highlighting its role as a tumor suppressor.

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In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
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In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity

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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
08:49

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
09:33

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity

Published on: January 5, 2016

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
10:58

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Context:

  • Phosphatidylethanolamine-binding protein (PEBP) is a conserved protein with diverse roles in cell signaling.
  • It modulates pathways like MAPK, PKC, G-protein-coupled receptor, and NF-kappaB.
  • PEBP is implicated in Alzheimer's disease and acts as a metastasis suppressor in tumors.

Purpose:

  • To explore the multifaceted roles of PEBP in biological processes.
  • To investigate PEBP's involvement in signal transduction, neurodegeneration, and cancer.
  • To understand the implications of PEBP dysregulation in diseases like colorectal cancer.

Summary:

  • PEBP inhibits the MAPK pathway (also known as Raf-1 kinase inhibitor protein, RKIP) and influences other signaling cascades.
  • It plays a role in Alzheimer's disease development as a precursor to HCNP.
  • PEBP acts as a tumor suppressor by inhibiting metastasis and promoting apoptosis, with its gene methylation linked to colorectal cancer metastasis.
  • Furthermore, PEBP regulates the cell cycle's spindle checkpoint, and its loss can cause chromosomal abnormalities.

Impact:

  • PEBP's function as a metastasis suppressor and its role in cell cycle regulation offer potential therapeutic targets for cancer.
  • Understanding PEBP's involvement in Alzheimer's disease may lead to new treatment strategies.
  • PEBP's broad signaling roles underscore its significance in cellular homeostasis and disease pathogenesis.