[New program PSI protein classifier automatizes the PSI-BLAST results analysis]

PSI Protein Classifier is a new program that allows to summarize the consecutive and independent PSI-BLAST iteration results. The technical opportunities of the program are explained. Two examples of the PSI Protein Classifier application are given. Iterative screening of the protein database allowed to reveal feasible evolutionary relationship among GH5, GH13, GH27, GH31, GH36, GH66, GH101, and GH114 families of glycoside hydrolases. Family GH31 is divided into 38 subfamilies on the basis of statistically significant sequence similarity analysis (E-value analysis).