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Recent advances in developing ophthalmic formulations: a patent review
1Parenteral Center of Emphasis, Global Research & Development, Pfizer Inc, Groton, CT 06340, USA. guang.w.lu@pfizer.com
Recent Patents on Drug Delivery & Formulation
|October 8, 2009
Summary
Researchers explored new ophthalmic formulations to enhance drug solubility, stability, and ocular bioavailability. Innovations include novel excipients and oil-in-water emulsions for improved drug delivery and ocular tolerance.
Area of Science:
- Ophthalmic drug delivery
- Formulation science
- Pharmaceutical technology
Background:
- Ophthalmic formulations face challenges in drug solubility, stability, and ocular bioavailability.
- Development of tolerable preservative systems is crucial for ocular tissues.
- Recent advancements focus on front-of-eye instillations.
Purpose of the Study:
- To review recent innovations in ophthalmic formulations over the past decade.
- To highlight advancements in drug solubility, stability, and ocular bioavailability.
- To identify promising technologies for treating ophthalmic diseases.
Main Methods:
- Review of patents and scientific literature on ophthalmic formulations.
- Analysis of novel excipient applications, including polymeric excipients, cyclodextrins, and stabilized chloride dioxide (SCD).
- Evaluation of oil-in-water (O/W) emulsions as an ophthalmic dosage form.
Main Results:
- Polymeric excipients, cyclodextrins, and stabilized chloride dioxide (SCD) are actively studied.
- Oil-in-water (O/W) emulsions show potential for increased drug solubility, API stabilization, and improved ocular tolerance.
- Several innovations demonstrate potential for new commercial ophthalmic products.
Conclusions:
- Recent advancements in ophthalmic formulation technology offer significant improvements.
- Novel excipients and dosage forms like O/W emulsions are key to enhanced drug delivery.
- These innovations hold promise for the advancement of ophthalmic disease treatment.
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