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Immunomodulatory activity of Acacia catechu
1Krupanidhi College of Pharmacy, #5, Sarjapur Road, Koramangala, Bangalore 560 034.
Indian Journal of Physiology and Pharmacology
|October 9, 2009
Summary
The aqueous extract of Acacia catechu, known as Katha, significantly boosts both cell-mediated and humoral immunity. This traditional herb demonstrates potent immunomodulatory effects, supporting immune system function.
Area of Science:
- Immunology
- Pharmacology
- Ethnobotany
Background:
- Acacia catechu (Katha) is a plant with a history of traditional medicinal use.
- Its immunomodulatory properties require scientific validation.
Purpose of the Study:
- To investigate the immunomodulatory effects of aqueous Acacia catechu extract.
- To assess its impact on both cell-mediated and humoral immunity.
Main Methods:
- The study utilized neutrophil adhesion tests, mice lethality tests, carbon clearance assays, and cyclophosphamide-induced neutropenia models.
- Serum immunoglobulin levels and hemagglutination tests were also performed.
Main Results:
- Acacia catechu extract enhanced neutrophil adhesion, phagocytic index, and protection against neutropenia, indicating cell-mediated immunity effects.
- The extract increased serum immunoglobulin levels, hemagglutination titers, and reduced mortality, suggesting humoral immunity effects.
Conclusions:
- Aqueous Acacia catechu extract exhibits significant immunomodulatory activity.
- The extract positively influences both the cell-mediated and humoral arms of the immune system.
