Fatty liver and liver transplantation

Area of Science:

• Hepatology
• Transplant Surgery
• Public Health

Background:

• Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are increasingly prevalent, linked to global obesity epidemics.
• These conditions represent significant public health concerns due to their association with overnutrition and obesity.

Purpose of the Study:

• To address the challenges posed by obesity and NAFLD in liver transplantation.
• To explore the management of donors and recipients with obesity-related liver conditions.

Main Methods:

• This article is a review and discussion of existing literature and clinical challenges.
• It synthesizes information on the impact of obesity and NAFLD on liver transplant outcomes.

Main Results:

• Obesity and NAFLD introduce complex comorbidities and hepatic effects in liver transplant candidates and donors.
• These factors necessitate specialized management strategies for both recipients and donors.

Conclusions:

• The rising prevalence of NAFLD and obesity presents substantial challenges for the liver transplant community.
• Effective management strategies are crucial for optimizing outcomes in this growing patient population.