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Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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Cirrhosis I: Introduction

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Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

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Chronic Pancreatitis II: Collaborative Care

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Assessment:
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Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
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Cholecystitis

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NASH and HCC.

John M Page1, Stephen A Harrison

  • 1Department of Medicine, Gastroenterology Service, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.

Clinics in Liver Disease
|October 13, 2009
PubMed
Summary
This summary is machine-generated.

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. The aggressive form, non-alcoholic steatohepatitis (NASH), may lead to liver cancer, including cases previously considered cryptogenic.

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Area of Science:

  • Hepatology
  • Oncology
  • Gastroenterology

Background:

  • Primary liver cancer is a major global health concern, ranking fifth in incidence and third in mortality.
  • Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease in the US.
  • NAFLD ranges from simple steatosis to non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma (HCC).

Purpose of the Study:

  • To investigate the role of NAFLD, particularly NASH, in the development of hepatocellular carcinoma (HCC).
  • To explore the contribution of NASH to the burden of cryptogenic HCC.

Main Methods:

  • This study reviews existing literature and epidemiological data on NAFLD, NASH, and HCC.
  • Analysis of patient data to identify correlations between NAFLD/NASH and HCC development.
  • Review of pathological findings in cryptogenic HCC cases.

Main Results:

  • NASH is an increasingly recognized risk factor for HCC development.
  • A significant proportion of HCC cases previously classified as cryptogenic may be attributable to underlying NASH.
  • Progression from simple steatosis to NASH increases the risk of HCC.

Conclusions:

  • NASH is a significant driver of hepatocellular carcinoma, including in cases without a clear diagnosis of chronic liver disease.
  • Increased awareness and diagnosis of NAFLD/NASH are crucial for HCC prevention and management.
  • Further research is needed to elucidate the precise mechanisms linking NASH to HCC.