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Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: Jun 19, 2026

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy &ndash; Adaptation for the COVID-19 Pandemic
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Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

[Primary ciliary dyskinesia. Ciliopathies].

Miguel Armengot Carceller1, Manuel Mata Roig, Xavier Milara Payá

  • 1Servicio de Otorrinolaringología, Hospital General Universitario, Facultat de Medicina, Universitat de València, Valencia, España. miguel.armengot@gmail.com

Acta Otorrinolaringologica Espanola
|October 13, 2009
PubMed
Summary

Primary ciliary dyskinesia (PCD) is an inherited disorder causing immotile cilia, leading to chronic infections and male infertility. Diagnosis involves analyzing cilia motility and structure.

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High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
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High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

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Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
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Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

Related Experiment Videos

Last Updated: Jun 19, 2026

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy &ndash; Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

Area of Science:

  • Genetics
  • Cell Biology
  • Medical Science

Context:

  • Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting cilia function.
  • Cilia are crucial for mucociliary clearance, reproduction, and organ positioning.
  • PCD impacts respiratory health, fertility, and can lead to situs inversus (Kartagener's syndrome).

Purpose:

  • To define primary ciliary dyskinesia (PCD) and its genetic basis.
  • To outline the diagnostic methods for PCD, including cilia motility analysis and ultrastructure examination.
  • To highlight the diverse clinical manifestations and potential for other ciliopathies resulting from ciliary dysfunction.

Summary:

  • Primary ciliary dyskinesia (PCD) is an inherited condition characterized by impaired cilia movement.
  • This dysfunction disrupts mucociliary clearance, causing recurrent respiratory infections from birth.
  • It also leads to male sterility due to immotile sperm and situs inversus in 40-50% of cases.

Impact:

  • Advances understanding of genetic disorders affecting cilia.
  • Improves diagnostic approaches for primary ciliary dyskinesia and related conditions.
  • Highlights the broad impact of ciliary dysfunction on human health, potentially leading to other ciliopathies.