[Immunohistochemical technique in hemopathology: the ways of improving differential diagnosis and the prospects]

The paper deals how to improve the differential diagnosis of lymphomas by an immunohistochemical study. The introduction of DNA chips for the study of the gene expression profile in different types of lymphomas has created conditions for the emergence of the new class of protein antibodies--target genes. New immunohistochemical algorithms are being developed; the antibodies, the products of cytogenetic anomalies, chimeric genes emerge, which gives rise to prospects for the wide introduction of immunohistochemistry into pathologoanatomic practice. From the new diagnostic points of view, some types of lymphomas, as given in the September 2008 WHO classification of hematopoietic and lymphoid tissue tumors, are considered.