[Individual differences in the response of target organs and the immune system in experimental endotoxicosis]

Individual morphofunctional differences were studied in the reaction of target organs and the immune system of Wistar rats given large-dose lipopolysaccharides (LPS). A cluster analysis of the indices characterizing the reaction of target organs and the immune system to PLS administration was used to divide the Wistar rats into 2 groups: 1) those with high production of Th1 cytokines (interleukin-2 and interferon-gamma) and 2) those with their low production. In the high production group, hepatic dystrophic changes and a pulmonary inflammatory reaction were more pronounced, which were associated with the alterative changes in the immune organs. On day 7, the morphofunctional differences in the reaction of target organs and the immune system were less marked and mainly seen at the functional level.