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[Renin-aldosterone system in patients with hypertensive form of chronic glomerulonephritis and preserved renal

N Iu Borovkova, N N Borovkov, B N Sidnev

    Klinicheskaia Meditsina
    |October 16, 2009
    PubMed

    Insights

    In chronic glomerulonephritis (CGN) patients with normal kidney function, plasma active renin (PAR) levels correlate with hypertension severity. Elevated plasma aldosterone (PAL) also appears in severe hypertension, suggesting a role for the renin-aldosterone system in CGN-related high blood pressure.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Cardiovascular Medicine

    Background:

    • Chronic glomerulonephritis (CGN) can affect kidney function and blood pressure.
    • The renin-aldosterone system plays a crucial role in regulating blood pressure.
    • Understanding its role in CGN with preserved renal function is important for managing hypertension.

    Purpose of the Study:

    • To assess the renin-aldosterone system's status in patients with hypertonic chronic glomerulonephritis (CGN) and preserved renal function.
    • To investigate the correlation between renin-aldosterone system activity and the severity of arterial hypertension (AH) in these patients.

    Main Methods:

    • Radioimmunoassay (RIA) was used to measure plasma active renin (PAR) and plasma aldosterone (PAL) levels.
    • 100 patients with hypertonic CGN and preserved renal function were studied.
    • A control group of 35 CGN patients without arterial hypertension was included.

    Main Results:

    • In normotensive CGN patients with preserved renal function, PAR and PAL levels were unaltered.
    • PAR levels tended to increase in CGN patients with AH and correlated with AH severity.
    • PAL levels were significantly elevated in CGN patients with grade II and III AH.

    Conclusions:

    • Elevated PAR levels likely play a significant role in the development of arterial hypertension in CGN patients with preserved renal function.
    • A trend towards increased PAL levels was observed in these hypertensive CGN patients.
    • The renin-aldosterone system is implicated in the pathogenesis of hypertension in CGN.

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