Related Experiment Video
Updated: Jun 19, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Vitreous metastases of primary cutaneous B-cell lymphoma
Deborah Y Chong1, Mark W Johnson, Defen Shen
1Texas Retina Associates, Arlington, TX, USA.
Purpose:
To describe two cases of vitreous metastases of primary cutaneous B-cell lymphoma (PCBCL).
Methods:
Observational case series.
Results:
A 73-year-old man and an 81-year-old woman, both with a history of PCBCL, diffuse large cell type, presented with decreased visual acuity due to vitritis. Both patients underwent vitreous biopsy that demonstrated B-cell lymphoma, large cell type, and confirmed metastases of cutaneous B-cell lymphoma to the vitreous.
Conclusion:
PCBCL, diffuse large cell type, is a rare form of non-Hodgkin lymphoma that can metastasize to the vitreous without visible chorioretinal involvement.
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