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The antigen processing pathway in B lymphocytes

C Watts1, P A Reid, M A West

  • 1Department of Biochemistry, University of Dundee, UK.

Seminars in Immunology
|July 1, 1990
PubMed

Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.

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