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Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Related Experiment Video

Updated: Jun 19, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Point-of-care testing in coagulation.

Elizabeth M Van Cott¹

¹Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

Clinics in Laboratory Medicine

|October 21, 2009

Summary

Point-of-care (POC) coagulation tests offer rapid results for platelet function, prothrombin time/international normalized ratio, D-dimer, and activated clotting time (ACT). Further research is needed to explore their full clinical potential and optimize heparin management.

Area of Science:

Clinical Chemistry
Hematology
Point-of-Care Diagnostics

Background:

Point-of-care (POC) assays provide rapid coagulation testing compared to central labs.
Current POC methods cover various coagulation parameters, enhancing clinical decision-making.
Simplicity and speed are key advantages of POC coagulation assays.

Purpose of the Study:

To review the current status of point-of-care coagulation testing methodologies.
To discuss the clinical applications and limitations of key POC coagulation tests.
To highlight future research directions for POC coagulation diagnostics.

Main Methods:

Review of existing literature on point-of-care coagulation assays.
Focus on methodologies for platelet function testing, PT/INR, D-dimer, and ACT.

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Analysis of clinical utility and performance characteristics.

Main Results:

POC assays are available for platelet function, PT/INR, D-dimer, and ACT, offering faster results.
Established clinical uses and limitations for each tested methodology are discussed.
Potential future applications in heparin management and advanced monitoring are identified.

Conclusions:

POC coagulation testing offers significant advantages in speed and ease of use.
Further studies are essential to fully realize the clinical impact of POC coagulation tests.
POC diagnostics hold promise for improved patient management, particularly in critical care settings.