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Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Thrombolysis for acute ischemic stroke

M Uyttenboogaart1, J De Keyser, G J Luijckx

  • 1Department of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands. m.uyttenboogaart@neuro.umcg.nl

Current Topics in Medicinal Chemistry
|October 24, 2009
PubMed

In the last decennium, thrombolytic therapy has changed the management of acute ischemic stroke. Randomized clinical studies have demonstrated that intravenous thrombolysis with tissue plasminogen activator improves functional outcomes. Recently the time window for intravenous thrombolysis has been extended from 3 to 4.5 hours after stroke onset, which will allow more stroke patients to benefit from this treatment. Currently several studies are investigating how to improve recanalization rates of thrombolytic therapy. In this review several aspects of intravenous and intra-arterial thrombolysis are discussed.

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