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The atopic march: what's the evidence?
1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennesse 37232-8300, USA.
Summary
The atopic march, a progression from eczema to asthma and allergic rhinitis, is supported by evidence. Refining early eczema phenotypes may improve prediction of later atopic diseases.
Area of Science:
- Allergy and Immunology
- Pediatric Medicine
- Dermatology
Background:
- The atopic march describes the common progression of allergic diseases in children.
- Early onset eczema is frequently observed as the initial manifestation.
Purpose of the Study:
- To review and compile data supporting the atopic march paradigm.
- To assess the precision and utility of the current atopic march definition.
Main Methods:
- A comprehensive PubMed search was conducted using keywords related to atopic march and allergic diseases.
- Relevant articles were reviewed and selected for data compilation and trend analysis.
Main Results:
- Data confirm the temporal progression from eczema to allergic rhinitis and asthma.
- The current definition of the atopic march lacks precision, impacting its clinical usefulness.
- Refining early eczema phenotypes (atopic vs. nonatopic) may enhance predictive value.
Conclusions:
- The atopic march serves as a useful model for understanding atopy progression in children.
- More precise phenotyping of early atopic march stages could improve prediction of comorbid chronic diseases.
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