Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

Ultrasound II: Endoscopic Ultrasound and FibroScan

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

Hepatic Portal System

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sincalide-stimulated cholescintigraphy: what is the standard?

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2010

Same author

Extended application of 99mTc-mebrofenin cholescintigraphy with cholecystokinin in the evaluation of abdominal pain of hepatobiliary and gastrointestinal origin.

Nuclear medicine communications·2010

Same author

Development and intra-institutional and inter-institutional validation of a comprehensive new hepatobiliary software: Part 1--Liver and gallbladder function.

Nuclear medicine communications·2009

Same author

Segmentation of the gallbladder: effect on bile entry and exit and its clinical relevance in a patient with abdominal pain.

Nuclear medicine communications·2007

Same author

Asymptomatic gallstone: What are its functional characteristics?

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2006

Same author

Effect of sequential administration of an opioid and cholecystokinin on gallbladder ejection fraction: brief communication.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2006

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Development and validation of a comprehensive new hepatobiliary software. Part II: Segmental liver function.

Gerbail T Krishnamurthy¹, Shakuntala Krishnamurthy, Thomas Milleson

¹Department of Nuclear Medicine and Radiology, Tuality Community Hospital, Hillsboro, Oregon 97123, USA. GTKrishna@aol.com

Nuclear Medicine Communications

|October 27, 2009

Summary

New hepatobiliary software quantifies liver function and size using 99mTc-HIDA scans, aiding surgical planning. This FDA-approved tool standardizes nuclear hepatology assessments for segmental and lobar liver evaluation.

More Related Videos

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

Published on: September 28, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

Published on: September 28, 2021

Area of Science:

Nuclear medicine
Hepatobiliary imaging
Medical software development

Background:

Accurate quantification of liver function and size is crucial for surgical planning and disease management.
Existing methods for assessing lobar and segmental liver function can be variable and lack standardization.

Purpose of the Study:

To develop and obtain FDA approval for novel hepatobiliary software designed to quantify segmental and lobar liver function.
To establish a standardized method for assessing liver size and function using 99mTc-HIDA cholescintigraphy.

Main Methods:

Development of JAVA-based hepatobiliary software compatible with PC and DICOM image data from gamma cameras.
Automated liver boundary detection and measurement of liver height at the right midclavicular line (RMCL).
Calculation of geometric mean areas for physiologic lobes and segmental liver function based on 5th-minute 99mTc-HIDA uptake.

Main Results:

In control participants, mean liver height at RMCL was 14.7 cm, with established geometric mean areas for right lobe (116 cm2), left lobe (96 cm2), and total liver (212 cm2).
Segmental liver function distribution was quantified: right upper (31%), right lower (34%), left medial (24%), left lateral (10%), and caudate lobe (1%).
Excellent correlation was observed between CT-defined liver volume and the software's quantitative assessment of liver size and function.

Conclusions:

The newly FDA-approved software offers a quantitative assessment of segmental, lobar, and total liver size and function from planar 99mTc-HIDA cholescintigraphy.
This tool has the potential to standardize nuclear hepatology practices universally.
Quantitative data provided by the software can assist surgeons in determining appropriate tissue resection volumes during liver surgery.