Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

Pneumonia II: Pathophysiology

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

Atypical Pneumonia

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

Pneumonia III: Complications and Assessment

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression.

Oncogene·2016

Same author

Emotional eating and risk of overweight among teenage girls.

Canadian journal of diabetes·2015

Same author

Colon carcinogenesis in inflammatory bowel disease.

Inflammatory bowel diseases·2013

Same author

Direct radioactive labeling of polymerase chain reaction products.

Methods in molecular biology (Clifton, N.J.)·2011

Same author

Determination of loss of heterozygosity using polymerase chain reaction.

Methods in molecular biology (Clifton, N.J.)·2011

Same author

Direct sequencing of polymerase chain reaction products.

Methods in molecular biology (Clifton, N.J.)·2011

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

EXPERIMENTAL CHEMICAL PNEUMONIA.

M Wollstein¹, S J Meltzer

¹Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Directly introducing chloramine-T or Dakin's solution into the lungs causes bronchopneumonia. These chemical-induced lung injuries differ from infectious pneumonia but suggest a natural defense mechanism against infection and intoxication.

More Related Videos

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

Published on: September 28, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

Published on: September 28, 2016

Area of Science:

Pulmonary Medicine
Toxicology
Pathology

Background:

The nasopharyngeal mucosa tolerates certain chloramine-T concentrations, but its effect on pulmonary tissue via direct bronchial introduction was unexplored.
Previous research by Kline and Meltzer indicated that various substances like aleuronat, starch, egg yolk, and lecithin could induce pulmonary inflammation.

Purpose of the Study:

To investigate the effects of direct intrabronchial administration of chloramine-T solutions and Dakin's solution on pulmonary tissue.
To compare the induced pulmonary lesions with those caused by other chemical substances and infectious agents.

Main Methods:

Intrabronchial injection of chloramine-T solutions and Dakin's solution in large volumes.
Observation and characterization of pulmonary lesions, including their progression and resolution.
Comparison with historical data on lung inflammation induced by aleuronat, starch, egg yolk, and lecithin.

Main Results:

Intrabronchial administration of chloramine-T and Dakin's solution induced extensive bronchopneumonia.
These lesions progressed for 2 days, then regressed, typically resolving by day 7.
Chemical-induced consolidations were sterile, unlike infectious pneumonia, and differed in fibrin content and type (bronchopneumonia vs. lobar pneumonia) depending on the substance.

Conclusions:

Direct bronchial introduction of certain chemical solutions can cause significant pulmonary injury, specifically bronchopneumonia.
Chemical-induced lung consolidations share similarities with infectious pneumonia but are sterile.
The anatomical findings in chemically induced pneumonia suggest a role in the body's defense and repair mechanisms against infection and intoxication.