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EXPERIMENTAL HIGH INTESTINAL OBSTRUCTION IN THE MONKEY.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Experimental high intestinal obstruction in monkeys caused a rise in non-protein nitrogen, similar to humans and dogs. Blood chloride levels dropped, and CO(2)-combining power increased, even without vomiting.
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Primate Research
Background:
- Intestinal obstruction is a critical condition with significant physiological consequences.
- Previous studies in humans and dogs have documented characteristic blood changes.
Purpose of the Study:
- To investigate the hematological changes associated with experimental high intestinal obstruction in non-human primates.
- To compare primate responses to known patterns in other species.
Main Methods:
- Five monkeys underwent experimental high intestinal obstruction.
- Blood samples were analyzed for non-protein nitrogen, chlorides, CO(2)-combining power, uric acid, and creatinine.
Main Results:
- All monkeys exhibited elevated non-protein nitrogen levels.
- A significant decrease in blood chlorides was observed in two monkeys, with a lesser fall in others.
- Increased CO(2)-combining power correlated with chloride level changes.
- Uric acid and creatinine showed no consistent alterations.
- Vomiting was not observed in any of the subjects.
Conclusions:
- High intestinal obstruction in monkeys elicits distinct blood chemistry alterations, including elevated non-protein nitrogen and decreased chlorides.
- The observed changes in blood chemistry, particularly the fall in chlorides and rise in CO(2)-combining power, occur independently of vomiting.
- These findings in primates contribute to understanding the pathophysiology of intestinal obstruction across species.
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