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THE SODIUM CONTENT OF THE BLOOD OF THE DOG AFTER EXPERIMENTAL INTESTINAL OBSTRUCTION
The Journal of Experimental Medicine
|October 30, 2009
Summary
Intestinal obstruction in dogs shows minimal plasma sodium changes but a rise in whole blood sodium. This suggests complex sodium shifts, not fully explained by electrolyte imbalances.
Area of Science:
- Veterinary Medicine
- Physiology
- Biochemistry
Background:
- Intestinal obstruction is a critical condition in veterinary medicine.
- Electrolyte and protein metabolism are significantly impacted by intestinal obstruction.
- Understanding sodium balance is crucial for managing this condition.
Purpose of the Study:
- To investigate the changes in blood sodium levels in dogs following experimental jejunal obstruction.
- To correlate sodium levels with other electrolytes like chloride and bicarbonate.
- To explore potential alterations in sodium binding or distribution post-obstruction.
Main Methods:
- Ten dogs underwent experimental jejunal obstruction.
- Blood samples were collected to determine plasma and whole blood sodium concentrations.
- Chloride and bicarbonate levels were also analyzed for comparison.
Main Results:
- Plasma sodium showed little change from the normal average of 336 mg/100 cc.
- Whole blood sodium levels demonstrated a tendency to increase after obstruction.
- Increased bicarbonate did not fully offset the decrease in chloride ions, indicating complex metabolic shifts.
Conclusions:
- Jejunal obstruction in dogs results in a notable increase in whole blood sodium.
- The observed sodium changes are not solely explained by alterations in chloride and bicarbonate.
- Further research is needed to elucidate the unknown sodium combinations and their role in intestinal obstruction pathophysiology.
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