REINFORCEMENT OF CONVALESCENT ANTIPOLIOMYELITIC SERUM IN THE MONKEY

A comparison has been made of the neutralizing value of pooled convalescent monkey serum for the filtered virus of poliomyelitis, before and after a series of reinforcement injections of the same virus strain. The strength of the pooled convalescent serum is increased by the reinforcing procedure. The original monkey convalescent serum had a neutralization value much below that of a pooled human convalescent serum. By reinforcement the neutralization value of the monkey serum was brought approximately to that of the human serum. One sample of serum from a supposedly normal child of 8 years exhibited a neutralizing value approximately equal to that of a pooled human convalescent serum and the reinforced pooled monkey serum.