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Updated: Jun 19, 2026
05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
Published on: December 4, 2015
SWINE INFLUENZA : I. EXPERIMENTAL TRANSMISSION AND PATHOLOGY.
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Researchers induced swine influenza in pigs, replicating the natural disease. This study details the pathology, including bronchial damage, lung collapse, and pneumonia, offering insights into the epizootic's characteristics.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Virology
Background:
- Swine influenza occurs epizootically in pigs.
- Understanding the pathogenesis of swine influenza is crucial for disease control.
Purpose of the Study:
- To experimentally induce and characterize swine influenza in pigs.
- To describe the clinical and pathological features of experimentally induced swine influenza.
Main Methods:
- Intranasal instillation of infectious material from spontaneous cases.
- Serial passages via intranasal instillation and pen contact.
- Establishment and characterization of eight virus strains.
Main Results:
- Experimental disease mirrored epizootic features.
- Clinical signs and mortality varied among eight virus strains.
- Pathology included exudative bronchitis, bronchial epithelial damage, pulmonary atelectasis, lymph node hyperplasia, and lobular pneumonia.
Conclusions:
- Swine influenza can be reliably induced experimentally.
- The study elucidated key pathological findings of swine influenza.
- Experimental models are valuable for studying swine influenza.
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