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Updated: Jun 19, 2026
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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
Published on: February 26, 2019
History matters: illuminating metaplasticity in the developing brain.
Sheng-Zhi Wang1, Huizhong Whit Tao
1Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Neuron
|October 31, 2009
Summary
Metaplasticity, the brain
Area of Science:
- Neuroscience
- Developmental Neuroscience
Background:
- Metaplasticity describes how neuronal plasticity is regulated by activity.
- Understanding metaplasticity is crucial for comprehending brain development and function.
Discussion:
- Dunfield and Haas investigated metaplasticity in developing brain circuits.
- They utilized specific visual stimulation patterns to probe neuronal plasticity.
Key Insights:
- Functional plasticity in individual neurons varies based on visual training.
- Time-averaged postsynaptic activity preceding visual training predisposes plasticity outcomes.
Outlook:
- This research offers insights into activity-dependent regulation of neuronal plasticity.
- Further studies can explore therapeutic interventions targeting metaplasticity.
