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A case report of cimetidine-induced clozapine toxicity
S Szymanski1, J A Lieberman, D Picou
1Psychiatric Research Department, Hillside Hospital, Glen Oaks, NY 11004.
The Journal of Clinical Psychiatry
|January 1, 1991
Abstract:
Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.