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Why we don't have an HIV vaccine, and how we can develop one
1Massachusetts Institute of Technology in Cambridge, Massachusetts, and Blackstone Valley Community Health Care in Pawtucket, Rhode Island, USA. jeffrey@mit.edu
Abstract:
Confronted with the recent high-profile failures of several clinical trials of promising candidate vaccines against HIV, many scientists have all but given up hope of producing a human-ready vaccine within the next decade. In this review I contend that although the scientific obstacles remain formidable, the economic challenges are just as real. The groundwork will be laid for a major scientific breakthrough in vaccine development only when there are new contractual structures that enhance private incentives for vaccine development; when we have clearly specified the rights to the profitable North American market; when we have established a system of liability protection for vaccine side effects; and when our clinical trials also test the behavioral consequences of vaccination.
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