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Updated: Dec 25, 2025
Surgical Labyrinthectomy of the Rat to Study the Vestibular System
Published on: May 19, 2018
[Expression of group I mGluRs in rat flocculus after unilateral labyrinthectomy]
1Department of Otorhinolaryngology, First Hospital of Zhengzhou University, Zhengzhou 450052, China.
Objective:
Studies revealed that cerebellar flocculus-paraflocculus complex plays an important in vestibular compensation. To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrinthectomy (UL).
Method:
After setting left labyrinthectomy, the change of Group I mGluRs was detected by RT-PCR.
Result:
Group I mGluR5 was induced increase in both side flocculus after unilateral labyrinthectomy. By contrast, mGluR1 was induced decrease. However, that of the lesioned side was stronger than that of the unlesioned side.
Conclusion:
UL can induce change of Group I mGluRs in the flocculus. The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still unknown.
