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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

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Related Experiment Video

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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Vascular morphogenesis in the zebrafish embryo.

Elín Ellertsdóttir1, Anna Lenard, Yannick Blum

  • 1Department of Cell Biology, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

Developmental Biology
|November 10, 2009
PubMed
Summary
This summary is machine-generated.

Vascular development in zebrafish embryos involves diverse cell behaviors for blood vessel formation. This study details the specific morphogenetic mechanisms driving vessel assembly and tube formation during early development.

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Last Updated: Jun 18, 2026

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Imaging and 3D Reconstruction of Cerebrovascular Structures in Embryonic Zebrafish

Published on: April 22, 2014

Area of Science:

  • Developmental Biology
  • Vascular Biology
  • Zebrafish Embryogenesis

Background:

  • Vertebrate vasculature undergoes extensive growth and remodeling during embryonic development.
  • Blood vessel formation (vasculogenesis and angiogenesis) involves a variety of complex cellular processes.
  • Understanding these mechanisms is crucial for comprehending embryonic development and vascular diseases.

Purpose of the Study:

  • To describe the vascular morphogenesis in the early zebrafish embryo.
  • To discuss the diverse morphogenetic mechanisms contributing to blood vessel assembly and tube formation.
  • To explore the molecular regulation of these complex cellular behaviors in vascular development.

Main Methods:

  • Observation and analysis of vascular development in early zebrafish embryos.
  • Detailed description of cellular and tissue-level events during blood vessel formation.
  • Discussion of relevant molecular pathways regulating vascular morphogenesis.

Main Results:

  • Identified and described multiple morphogenetic mechanisms including budding, cord hollowing, cell hollowing, cell wrapping, and intussusception.
  • Demonstrated the contribution of these diverse mechanisms to vessel assembly, sprouting, and tube formation in different blood vessels.
  • Highlighted the role of specific molecular pathways in orchestrating these complex cellular behaviors.

Conclusions:

  • Early zebrafish embryos exhibit a rich diversity of morphogenetic mechanisms for vascular development.
  • These mechanisms collectively contribute to the intricate process of blood vessel assembly and maturation.
  • Molecular pathways play a key role in regulating the complex cell behaviors underlying vascular morphogenesis.