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Related Concept Videos

Excess Pressure Inside a Drop and a Bubble01:13

Excess Pressure Inside a Drop and a Bubble

The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.

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Related Experiment Video

Updated: Jun 18, 2026

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

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Published on: May 9, 2021

Cavitation microstreaming and stress fields created by microbubbles.

James Collis1, Richard Manasseh, Petar Liovic

  • 1Department of Mechanical Engineering, University of Melbourne, VIC 3010, Melbourne, Australia.

Ultrasonics
|November 10, 2009
PubMed
Summary
This summary is machine-generated.

Ultrasound-driven microbubbles create cavitation microstreaming patterns that enhance therapeutic effects. Changing sound frequency alters these patterns, offering a new method for improving sonoporation and sonothrombolysis.

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A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Area of Science:

  • Acoustic cavitation
  • Biomedical engineering
  • Ultrasound therapeutics

Background:

  • Cavitation microstreaming from microbubbles is key to ultrasound therapies like sonoporation and sonothrombolysis.
  • Understanding microbubble behavior near surfaces is crucial for optimizing these treatments.

Purpose of the Study:

  • To investigate the diverse microstreaming patterns around surface-bound microbubbles driven by ultrasound.
  • To analyze the relationship between oscillation modes, sound frequency, and resulting shear stress/stretch distributions.
  • To evaluate the potential of frequency-based pattern control for enhancing therapeutic ultrasound applications.

Main Methods:

  • Utilized microscopic particle-image velocimetry (micro-PIV) to visualize and analyze microstreaming patterns.
  • Experimented with microbubbles significantly larger than those used clinically.
  • Varied ultrasound driving frequency to observe changes in microstreaming patterns and associated forces.

Main Results:

  • Identified multiple distinct microstreaming patterns around surface-bound microbubbles, each linked to specific oscillation modes.
  • Demonstrated that changing sound frequency effectively switches between these patterns.
  • Observed significant variations in shear stress and stretch/compression distributions across different patterns, impacting therapeutic efficacy zones.

Conclusions:

  • Ultrasound-driven microstreaming is a viable mechanism for therapeutic agent mixing and molecular delivery across cell membranes.
  • Frequency-dependent microstreaming patterns offer a controllable method to potentially enhance sonoporation and sonothrombolysis.
  • Frequency-based pattern alternation presents a promising alternative to increasing acoustic pressure for therapeutic enhancement.