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Updated: Jun 18, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Reusable localized surface plasmon sensors based on ultrastable nanostructures.

Nicolas Vogel¹, Mathieu Jung, Noelia L Bocchio

¹Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

Small (Weinheim an Der Bergstrasse, Germany)

|November 10, 2009

Summary

This study presents a stable gold nanoparticle sensing platform for biological applications. The robust silicon dioxide matrix ensures high performance in aqueous solutions, enabling reusable biosensing.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Nanoparticle arrays are crucial for sensing due to localized surface plasmon resonances (LSPRs).
Conventional arrays lack stability in aqueous media, limiting biological applications.
A need exists for robust, reusable nanoscale sensing platforms.

Purpose of the Study:

To develop a stable and reusable nanoscale sensing platform.
To overcome the limitations of conventional nanoparticle arrays in biological sensing.
To leverage LSPRs for enhanced sensitivity in aqueous environments.

Main Methods:

Fabrication of gold nanoparticle arrays using nanosphere lithography.
Embedding nanoparticles within a silicon dioxide matrix for enhanced stability.

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography

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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

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Characterization of the platform's stability and reusability in aqueous solutions.

Main Results:

The developed platform demonstrates exceptional stability in aqueous and buffer solutions.
The silicon dioxide matrix effectively protects the gold nanoparticles.
The platform can be regenerated multiple times via simple mechanical cleaning.
The ultraflat surface is ideal for bio-oriented sensing.

Conclusions:

The presented nanoscale sensing platform offers a robust and reusable solution for biosensing.
Embedding gold nanoparticles in silicon dioxide enhances stability for biological applications.
This architecture provides a promising substrate for sensitive and reliable biosensing.