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Updated: Jun 18, 2026
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
Comparative assessment of heart remodeling in rats after experimental coronary stenosis and cryodestruction
S A Afanasiev1, U V Rogovskaya, L P Falaleeva
1Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. tursky@cardio.tsu.ru
Abstract:
Comparative analysis of myocardial changes due to heart remodeling after experimental coronary stenosis and cryodestruction in rats was performed. Similar picture of heart remodeling was observed in all animals on day 45 irrespective of the type of destruction: hypertrophy of intact myocardium of the left ventricle, formation of extensive connective tissue cicatrix, and similar structural changes in the myocardium adjacent to the damage area. The type of the damaging influence possibly plays a role at the stage of lesion formation. We concluded that the proposed method of cryodestruction induces heart remodeling comparable to that observed after coronary occlusion.
