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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Related Experiment Video

Updated: Jun 18, 2026

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Blastocyst transfer for multiple prior IVF failure: a five year descriptive study.

A P H Walsh1, L V Shkrobot, G D Coull

  • 1The Sims Institute/Sims International Fertility Clinic, Rosemount Hall, Dundrum Road, Dublin 14.

Irish Medical Journal
|November 12, 2009
PubMed
Summary
This summary is machine-generated.

Blastocyst transfer (BT) offers hope for patients with multiple failed in vitro fertilization (IVF) cycles. Extended embryo culture and BT should be considered for these challenging cases, showing comparable success rates despite increased prior IVF failures.

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Published on: October 18, 2024

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Embryology

Background:

  • Recurrent in vitro fertilization (IVF) failure is associated with poor prognosis, especially in women over 35.
  • Patients with multiple prior unsuccessful IVF cycles often face limited treatment options.

Purpose of the Study:

  • To evaluate the clinical outcomes of blastocyst transfer (BT) in patients with a history of multiple failed IVF cycles.
  • To compare reproductive outcomes between two cohorts of poor-prognosis IVF patients undergoing their first BT, separated by a five-year interval.

Main Methods:

  • A retrospective comparison of two groups of patients undergoing their first blastocyst transfer (BT).
  • Group 1: Treated in 2002 (n=66); Group 2: Treated in 2007 (n=392).
  • Clinical features and reproductive outcomes, including clinical pregnancy rates, were analyzed.

Main Results:

  • Both groups had similar mean ages (around 36 years) and oocyte retrieval numbers.
  • Clinical pregnancy rates were comparable: 59.6% in 2002 vs. 50.0% in 2007.
  • The 2007 group had significantly more prior failed IVF cycles (4.5 vs. 3.5), with no significant difference in BT success rates.

Conclusions:

  • Blastocyst transfer (BT) can achieve successful clinical pregnancy rates in patients with multiple prior unsuccessful IVF cycles.
  • Extended embryo culture and BT should be considered for refractory IVF patients.
  • Further controlled studies are necessary to define the precise role of BT in this patient sub-group.