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In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
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Topical antibacterial agents.

Peter A Lio1, Elaine T Kaye

  • 1Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 1600, Chicago, IL 60611, USA. p-lio@northwestern.edu

Infectious Disease Clinics of North America
|November 14, 2009
PubMed
Summary
This summary is machine-generated.

Topical antibacterial agents offer advantages like reduced systemic toxicity and increased site concentration. This review examines their use in preventing and treating skin and wound infections.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Topical antibacterial agents offer localized treatment with reduced systemic side effects.
  • Advantages include ease of application and higher drug concentrations at the infection site.

Purpose of the Study:

  • To review the literature on topical antibacterial agents for specific indications.
  • To examine agents used in prophylaxis and treatment of skin and wound infections.

Main Methods:

  • Literature review of selected indications for topical antibacterials.
  • In-depth examination of specific topical antibacterial agents.

Main Results:

  • Topical agents provide decreased systemic toxicity compared to oral or IV routes.
  • Enhanced drug concentrations at the target site improve efficacy.
  • Ease of application is a significant benefit for patient compliance.

Conclusions:

  • Topical antibacterial agents are valuable for managing skin and wound infections.
  • Their favorable pharmacokinetic profile supports their use in prophylaxis and treatment.
  • Further research can optimize the application and selection of these agents.