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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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When less is more: TPJ and default network deactivation during encoding predicts working memory performance.

Alan Anticevic1, Grega Repovs, Gordon L Shulman

  • 1Department of Psychology, Campus Box 1125, Washington University, Saint Louis, MO 63130, USA. aanticev@artsci.wustl.edu

Neuroimage
|November 17, 2009
PubMed
Summary
This summary is machine-generated.

Greater deactivation in the temporo-parietal junction (TPJ) and default mode network (DMN) during working memory (WM) encoding predicts better performance. This suppression is crucial for forming accurate WM traces.

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Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • The temporo-parietal junction (TPJ), part of the ventral attention network, typically deactivates during demanding cognitive tasks.
  • This deactivation, along with the default mode network (DMN), is thought to prevent reorientation to irrelevant stimuli during tasks like working memory (WM).

Purpose of the Study:

  • To investigate if the magnitude of TPJ and DMN deactivation during WM encoding predicts subsequent WM performance.
  • To explore functional dissociations and connectivity patterns between TPJ and DMN during WM tasks.

Main Methods:

  • Utilized slow event-related functional magnetic resonance imaging (fMRI).
  • Employed a delayed WM task with distractor stimuli presented during the maintenance phase.
  • Analyzed TPJ and DMN activity and functional connectivity.

Main Results:

  • Increased TPJ and DMN deactivation during the encoding phase correlated with better WM performance.
  • TPJ responded to distractors with task-relevant features, unlike the DMN.
  • TPJ exhibited strong functional connectivity with the DMN during encoding, but not during distractor presentation.

Conclusions:

  • TPJ suppression is functionally important for cognitive engagement.
  • TPJ and DMN deactivation are critical for successful working memory trace formation.
  • TPJ can flexibly couple with the DMN based on task demands, even when not part of the resting-state DMN.