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Related Experiment Video

Updated: Jun 18, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Epothilones in prostate cancer.

William K Kelly¹

¹Department of Medicine and Surgery, Yale School of Medicine, Yale Comprehensive Cancer Center, New Haven, CT 06520, USA. william.kelly@jefferson.edu

Urologic Oncology

|November 17, 2009

Summary

Epothilones show promise for treating castration-resistant prostate cancer (CRPC) when standard treatments fail. These agents demonstrate efficacy and tolerability in early trials, offering new hope for patients with limited options.

Area of Science:

Oncology
Pharmacology

Background:

Castration-resistant prostate cancer (CRPC) has limited treatment options.
Taxane-based regimens offer minimal survival benefits and frequent relapse.
Novel therapeutic classes are needed for patients progressing beyond standard care.

Purpose of the Study:

To review the preclinical and clinical activity of epothilones in CRPC.
To evaluate epothilones as a potential new treatment for CRPC.

Main Methods:

Literature search of PubMed and congress abstract databases.
Focus on well-designed preclinical reports and clinical studies.
Identification of clinical data on epothilone use in CRPC.

Main Results:

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Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

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Published on: September 8, 2017

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

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Epothilones demonstrated preclinical activity in taxane-resistant CRPC cell lines.

Ixabepilone, sagopilone, and patupilone showed clinical activity and tolerability in Phase II CRPC trials.

Conclusions:

Epothilones exhibit efficacy in treating CRPC.
Further studies are needed to define optimal use, including dosing, combinations, and biomarkers.