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Updated: Jun 18, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Epothilones in prostate cancer

William K Kelly1

  • 1Department of Medicine and Surgery, Yale School of Medicine, Yale Comprehensive Cancer Center, New Haven, CT 06520, USA. william.kelly@jefferson.edu

Urologic Oncology
|November 17, 2009
PubMed
Abstract

Insights

Epothilones show promise for treating castration-resistant prostate cancer (CRPC) when standard treatments fail. These agents demonstrate efficacy and tolerability in early trials, offering new hope for patients with limited options.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Castration-resistant prostate cancer (CRPC) has limited treatment options.
  • Taxane-based regimens offer minimal survival benefits and frequent relapse.
  • Novel therapeutic classes are needed for patients progressing beyond standard care.

Purpose of the Study:

  • To review the preclinical and clinical activity of epothilones in CRPC.
  • To evaluate epothilones as a potential new treatment for CRPC.

Main Methods:

  • Literature search of PubMed and congress abstract databases.
  • Focus on well-designed preclinical reports and clinical studies.
  • Identification of clinical data on epothilone use in CRPC.

Main Results:

  • Epothilones demonstrated preclinical activity in taxane-resistant CRPC cell lines.
  • Ixabepilone, sagopilone, and patupilone showed clinical activity and tolerability in Phase II CRPC trials.

Conclusions:

  • Epothilones exhibit efficacy in treating CRPC.
  • Further studies are needed to define optimal use, including dosing, combinations, and biomarkers.

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