Collagenase for enzymatic debridement: a systematic review

Area of Science:

• Wound Care
• Dermatology
• Biochemistry

Background:

• Debridement is crucial for wound bed preparation.
• Multiple debridement techniques are available in clinical practice.

Purpose of the Study:

• To systematically review and rank evidence on the safety and efficacy of collagenase for debridement.
• To compare collagenase with sham ointment and other debridement methods.

Main Methods:

• Systematic review of studies comparing collagenase.
• Inclusion of comparisons against inactive ointment, autolytic, and surgical debridement.

Main Results:

• A significant body of evidence supports collagenase ointment's safety and effectiveness.
• Collagenase is effective for debriding cutaneous ulcers and burn wounds.

Conclusions:

• Collagenase ointment is a safe and effective enzymatic debriding agent.
• It is a recommended option for wound bed preparation in specific wound types.